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The WHO criteria incorporates known clinical features,and, as discussed in Hematotoxicity Section 5.2, morphology,cytochemistry, immunophenotype, genetics, epidemiology,etiology, and prognostic features.

The new classi?cation of disruptive mooddysregulation disorder (DMDD) was established to distinguish between childrenwho evidenced symptoms of “severe and persistent irritability” (APA, 2013,p. The detailed features ofasarcomere are shown at higher magnification in Figure 11.10a.The presenceofthe connective tissue in theextracellular space between the fibers constitutes the endomysium ofthe muscle. The major differencebetween a conventional and a confocal microscope is the addi-tion of a detector aperture (pinhole) that is rowjugate withthe focal point of the lens; therefore, it is confocal

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The main issue here for readers of research is the importance of evaluat-ing the quality of any measurements used. The most characteristic feature at thisstage is an extensive concentration ofvesicles and small lipiddroplets around the nucleus and extending toward bothpoles of the cell. It should be clear that internal validity must be dealt with in any study before exter-nal validity can be considered. Diphtheria: For acute stage as well as forcarriers—7 day treatment is recommended.Some prefer it over penicillin. Whether this has actually led to animprovement of their status within medicine is uncertain

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